Dry reaction of dialkyl phosphite with aldehydes in the presence of acetic anhydride for the synthesis of 1-acetoxyphosphonates on solid bases

Reaction of benzaldehyde with diethyl phosphite and acetic anhydride successively on different solid bases (oxides and carbonates) without the use of solvent were investigated. A simple, efficient, and new method has been developed for the synthesis of alpha-acetoxyphosphonates from aldehydes through a one-pot reaction of aldehydes with diethyl phosphite in the presence of acetic anhydride under solvent-free conditions using potassium or sodium carbonate. This method is easy, rapid, and high yielding for the one-pot synthesis of alpha-acetoxyphosphonates from aldehydes.