Journal
ARKIVOC
Volume -, Issue -, Pages 181-191Publisher
ARKAT USA INC
DOI: 10.3998/ark.5550190.0008.f18
Keywords
tuberculosis; isoniazid; nicotinic acid; analogs
Categories
Ask authors/readers for more resources
Several nicotinic and isoniazid derivatives, most of them containing nitro groups were synthesized by our group, and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration ( MIC) in mg/mL. The compound 11d exhibited the best result (1.2 mu g/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP). Therefore this class of compounds could be a good starting point to develop new lead compounds in the treatment of multi-drug resistant tuberculosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available