Journal
FREE RADICAL RESEARCH
Volume 41, Issue 1, Pages 98-U50Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760600935567
Keywords
tocopherol; vitamin E; smooth muscle; oligonucleotide-arrays; microarrays; cytoskeleton
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Funding
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES011985] Funding Source: NIH RePORTER
- NIEHS NIH HHS [R01 ES011985, R01 ES011985-03, R01 ES011985-02, R01 ES011985-01A2, ES 011985, ES 011985-02] Funding Source: Medline
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alpha-tocopherol (alpha-T) may affect biological processes by modulating mRNA concentrations. This study screened the responses of, similar to 15,000 lung mRNAs to dietary alpha-T in mice. The lung was chosen as the target organ because it is subjected to cyclical variations in oxidant and inflammatory stressors and alpha-T has been implicated in their modulations. The analysis identified, similar to 400 mRNAs sensitive to alpha-T status of lungs determined by dietary alpha-T. The female lung transcriptome appears to be more sensitive to the alpha-T status than that of the male lungs. Here, we focus on the induction of 13 cytoskeleton genes by dietary alpha-T because they were similarly induced in the male and the female lungs. Their inductions were confirmed by quantitative-real-timepolymerase chain reaction (qRT-PCR). Immunohistochemical analyses of three of the encoded proteins suggest that they are expressed in lung vasculature and alveolar regions. The data suggest that the lung alpha-T status may modulate cytoarchitecture of lungs.
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