Journal
ARKIVOC
Volume -, Issue -, Pages 246-254Publisher
ARKAT USA INC
DOI: 10.3998/ark.5550190.0008.f24
Keywords
alpha-aminophosphonate; antimicrobial activity; indole-3-carboxaldehyde
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alpha-Aminophosphonates (4a-I) were synthesized in high yields by the Kabachnik-Fields reaction. One-pot simultaneous reaction of indole-3-carboxaldehyde, a dialkyl- or diphenyl phosphite, and different heterocyclic-, cyclic-, or other primary amines in the presence of tetramethylguanidine (10 mole %) as catalyst in toluene at reflux temperature afforded 4a-I. They exhibited moderate to high antimicrobial activity.
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