Journal
JOURNAL OF NATURAL PRODUCTS
Volume 70, Issue 1, Pages 33-38Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np060462b
Keywords
-
Funding
- NATIONAL CANCER INSTITUTE [R01CA047135] Funding Source: NIH RePORTER
- NCI NIH HHS [CA 47135, R01 CA047135-17, R01 CA047135] Funding Source: Medline
Ask authors/readers for more resources
Bioassay-guided fractionation of Papua New Guinea collections of Leucosolenia sp. resulted in the isolation of the novel compounds leucosolenamines A (5) and B (6) and the known compound thymidine (7). Compound 5 contains a 2-aminoimidazole core substituted at C-4 and C-5 by an N,N-dimethyl-5,6-diaminopyrimidine-2,4-dione and a benzyl group, respectively. Compound 6 retains the same core structure; however C-4 is substituted by a 5,6-diamino-1,3-dimethyl-4-(methylimino)-3,4-dihydropyrimidin-2(1H)-one moiety. This substitution pattern is unique and has never been observed in calcareous imidazole alkaloid chemistry. Leucosolenamine A (5) was mildly cytotoxic against the murine colon adenocarcinoma C-38 cell line.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available