Journal
CLINICA CHIMICA ACTA
Volume 375, Issue 1-2, Pages 36-42Publisher
ELSEVIER
DOI: 10.1016/j.cca.2006.07.019
Keywords
HMGB1; cytokine; inflammation; sepsis; necrosis
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High mobility group box I (HMGB 1) exhibits unique biochemical functions as a biologically intrinsic requisite factor and as a toxin. As such, it is imperative to understand the mechanism by which these seemingly and diametrically opposed functions are exerted. To effectively discriminate these actions is important to accurately and precisely determine the concentration of HMGB 1 in biological samples. Research in this fascinating field, however, has been lacking due to the absence of a simple analytical system for HMGB1 that can be adapted for large sample numbers. In this report, we review the physiological and pathological significance of HMGB I and describe the development of an assay method for this pleiotropic protein. (c) 2006 Elsevier B.V. All rights reserved.
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