Journal
JOURNAL OF NATURAL PRODUCTS
Volume 70, Issue 1, Pages 89-94Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np060464w
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Funding
- NCI NIH HHS [R01-CA047135, R01 CA047135-17, R01 CA047135] Funding Source: Medline
- NCRR NIH HHS [S10-RR19918, S10 RR019918] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA047135] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR019918] Funding Source: NIH RePORTER
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An in-depth LCMS examination of 14 different collections of Indo-Pacific Theonella swinhoei sponges resulted in the discovery of four diastereomeric analogues of the cyclic pentapeptide motuporin. These motuporin analogues all contain a novel 2R configuration for the Adda amino acid. Additionally, one analogue has a unique nonoxygenated Adda amino acid. In all, 15 different compounds were observed by LCMS or isolated. The stereochemistries of the constituent amino acids were determined through a combination of the advanced Marfey technique and H-1 NMR data.
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