Journal
DYES AND PIGMENTS
Volume 73, Issue 1, Pages 7-12Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2005.10.001
Keywords
azure A; gram-negative; gram-positive; PACT; phenothiaziniums; photobactericide; photosensitiser; toluidine blue O
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The synthesis of chromophoric di- and trimethyl derivatives of azure A has been carried out along with the physicochemical profiling of the resulting derivatives. Structure-function relationships of the derivatives are proposed with a view to the development of novel photosensitisers with antimicrobial applications. All derivatives exhibited similar magnitudes of photosensitising efficacy in vitro to the standard dyes, azure A and toluidine blue O, but were generally more lipophilic in nature. Chromophoric methylation furnished more active photoantibacterials compared to the lead compounds, both against Gram-positive and Gram-negative organisms. (c) 2005 Elsevier Ltd. All rights reserved.
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