Journal
NATURE NEUROSCIENCE
Volume 10, Issue 9, Pages 1128-1130Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1952
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS038580] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS38580] Funding Source: Medline
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Parvalbumin- and cholecystokinin ( CCK)-expressing basket cells provide two parallel, functionally distinct sources of perisomatic inhibition to postsynaptic cells. We show that exogenously applied CCK enhances the output from rat parvalbumin-expressing basket cells, while concurrently suppressing GABA release from CCK-expressing neurons through retrograde endocannabinoid action. These results indicate that CCK may act as a molecular switch that determines the source of perisomatic inhibition for hippocampal principal cells.
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