Journal
NATURE NEUROSCIENCE
Volume 10, Issue 9, Pages 1131-1133Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1949
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P50HL060292] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS033987] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [F32DA017543] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL60292] Funding Source: Medline
- NIDA NIH HHS [F32 DA017543] Funding Source: Medline
- NINDS NIH HHS [NS33987] Funding Source: Medline
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Fever is a result of the action of prostaglandin E2 ( PGE2) on the brain and appears to require EP3 prostaglandin receptors ( EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nucleus of mice resulted in abrogation of the fever response. These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses.
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