Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 189, Issue 1-2, Pages 31-40Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2007.06.016
Keywords
autoimmunity; EAE/MS; histopathology; neuroimmunology; staging
Categories
Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS039434] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01 NS039434-04, R01 NS039434, NS-39434] Funding Source: Medline
Ask authors/readers for more resources
Mechanism-oriented studies of EAE rely mostly on gene-modified mice on the C5713L/6 background. Here we report that MP4-induced EAE displays characteristic differences in CNS pathology as compared to MOG peptide 35-55-elicited disease. While in the latter, the topology of CNS infiltration remained unchanged throughout the disease, in MP4-induced EAE it was dynamic and stage-dependent shifting from the brain to the spinal cord and finally to the cerebellum. Unlike in the MOG peptide model, the frequencies and sizes of CNS lesions in MP4-induced disease showed a clear correlation with clinical disease severity. These characteristic features of MP4-induced EAE may contribute to modelling the complex spectrum of disease manifestations seen in MS. (C) 2007 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available