Journal
CARDIOVASCULAR RESEARCH
Volume 75, Issue 4, Pages 649-658Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.cardiores.2007.06.020
Keywords
angiogenesis; arteries; atherosclerosis; coronary disease; inflammation
Categories
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL065342] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000305] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL65342, R01 HL065342-06, R01 HL065342] Funding Source: Medline
- NIBIB NIH HHS [R01 EB000305-10, EB000305, R01 EB000305] Funding Source: Medline
Ask authors/readers for more resources
The function of vasa vasorurn is both to deliver nutrients and oxygen to arterial and venous walls and to remove waste products, either produced by cells in the wall or introduced by diffusional transport through the endothelium of the artery or vein. Although the relationship between changes in vasa vasorum characteristics and the development of atheromatous plaques is well documented, the role of vasa vasorurn, especially in terms of their appearance and disappearance in disease processes such as atherosclerosis, are still not clearly understood in terms of their being causative or merely reactive. However, even if their proliferation is merely reactive, these new microvessels may be a source of disease progression by virtue of endothelial impairment and as a pathway for monocytic cells to migrate to sites of early disease. As both these features are aspects of the vasa vasorum function, this Review focuses on the following issues: 1) acute modulation of vasa vasorum patency due to surrounding compressive forces within vessel wall and due to variable tone in the smooth muscle within proximal vasa vasorum and 2) chronic angiogenic responses due to local cytokine accumulations such as occur in the wall of arteries in the presence of hypertension, hypercholesterolemia, accumulation of lipids, extravasated blood products (e.g., red blood cells, macrophages, inflammatory products) which attract monocytes, and response of vasa vasorum to phannacological stirnuli. (c) 2007 European Society of Cardiology. Published by Elsevier B.V All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available