Journal
ELECTROANALYSIS
Volume 19, Issue 12, Pages 1281-1287Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.200703848
Keywords
nucleoside osmium complexes; DNA and RNA; electroactive labels; mercury electrodes; nucleic acid voltammetry
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Osmium tetroxide complexes with nitrogen ligands [Os(VIII)L] have been widely applied as probes of the DNA structure and as electroactive labels of DNA. Here we describe the electrochemical behavior of Os(VIII)2,2-bipyridine (Os, bipy)-base-labeled nucleosides. We show that electroactive label can be introduced also in the nucleoside ribose residues using six-valent osmium complex. Cyclic voltammograms of sugar-Os (VI) -modified ribosides are similar but not identical to those of the base-modified ribosides. Our results showing the electroactivity of sugar modified ribosides pave the way to facile end-labeling of RNA.
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