Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 24, Issue 6, Pages 1283-1285Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msm061
Keywords
evolution; gene expression; selection pressure; microarray; exon array
Funding
- NHGRI NIH HHS [R01HG002341] Funding Source: Medline
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG002341] Funding Source: NIH RePORTER
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Microarray data from multiple species have been used to study evolutionary constraints on gene expression. Expression measurements from conventional microarray platforms such as the 3' expression arrays are strongly affected by platform-dependent probe effects that may introduce apparent but misleading discrepancies between species. In this manuscript, we assess the conservation of mammalian gene expression in adult tissues using data from a high-density exon array platform. The exon arrays have more than 6 million probes on a single array targeting all exons in a genome. We find that, unlike 3' array data, gene expression measurements from exon arrays reveal patterns of gene expression that are highly conserved between humans and mice in multiple tissues. Our analysis provides strong evidence for widespread stabilizing selection pressure on transcript abundance during mammalian evolution.
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