Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1768, Issue 4, Pages 952-963Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2006.11.002
Keywords
CXCR4; receptor regulation; phosphorylation; cancer; WHIM syndrome; signaling
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM044944, R37GM047417] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R37 GM047417-13, R37 GM047417, R01 GM044944-16, R01 GM044944] Funding Source: Medline
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The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors, and is directly involved in a number of biological processes including organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome. Importantly, the involvement of CXCR4 in cancer metastasis and WHIM syndrome appears to be due to dysregulation of the receptor leading to enhanced signaling. Herein we review what is currently known regarding the regulation of CXCR4 and how dysregulation contributes to disease progression. (c) 2006 Elsevier B.V. All rights reserved.
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