Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1768, Issue 4, Pages 794-807Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2006.10.021
Keywords
GPCR; 7TM; structure; conformational change; efficacy
Categories
Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R37NS028471] Funding Source: NIH RePORTER
- NINDS NIH HHS [R37 NS028471] Funding Source: Medline
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G protein coupled receptors (GPCRs) are remarkably versatile signaling molecules. The members of this large family of membrane proteins are activated by a spectrum of structurally diverse ligands, and have been shown to modulate the activity of different signaling pathways in a ligand specific manner. In this manuscript I will review what is known about the structure and mechanism of activation of GPCRs focusing primarily on two model systems, rhodopsin and the beta(2) adrenoceptor. (c) 2006 Elsevier B.V All rights reserved.
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