Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1768, Issue 4, Pages 825-835Publisher
ELSEVIER
DOI: 10.1016/j.bbamem.2006.09.021
Keywords
G protein-coupled receptor; dimerisation; signal transduction
Categories
Funding
- Medical Research Council [G9811527] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [G9811527] Funding Source: UKRI
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The belief that G protein-coupled receptors exist and function as monomeric, non-interacting species has been largely supplanted in recent years by evidence, derived from a range of approaches, that indicate they can form dimers and/or higher-order oligomeric complexes. Key roles for receptor homo-dimerisation include effective quality control of protein folding prior to plasma membrane delivery and interactions with hetero-trimeric G proteins. Growing evidence has also indicated the potential for many co-expressed G protein-coupled receptors to form hetero-dimers/oligomers. The relevance of this to physiology and function is only beginning to be unravelled but may offer great potential for more selective therapeutic intervention. (c) 2006 Elsevier B.V. All rights reserved.
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