Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1768, Issue 4, Pages 1006-1018Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2007.02.010
Keywords
G protein-coupled receptors; signaling; beta-arrestin; endocytosis
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL056687, P01HL075443] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL056687, P01 HL075443] Funding Source: Medline
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G protein-coupled receptors (GPCRs) are widely implicated in human heart disease, making them an important target for cardiac drug therapy. The most commonly studied and clinically targeted cardiac GPCRs include the adrenergic, angiotensin, endothelin, and adenosine receptors. Treatment options focusing on the complex and integrated signaling pathways of these GPCRs are critical for the understanding and amelioration of heart disease. The focus of this review is to highlight the most commonly studied and clinically targeted cardiac GPCRs, placing emphasis on their common signaling components implicated in cardiac disease. (c) 2007 Elsevier B.V. All rights reserved.
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