Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 184, Issue 1-2, Pages 37-44Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2006.11.015
Keywords
multiple sclerosis; CNS demyelinating autoimmune disease; inflammation; neuron degeneration; experimental autoimmune encephalomyelitis
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS040350] Funding Source: NIH RePORTER
- NINDS NIH HHS [5R01NS40350, R01 NS040350] Funding Source: Medline
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Although axonal loss has been observed in demyelinated multiple sclerosis (MS) lesions, there has been a major focus on understanding mechanisms of demyelination. However, identification of markers for axonal damage and development of new imaging techniques has enabled detection of subtle changes in axonal pathology and revived interest in the neurodegenerative component of MS. Axonal loss is generally accepted as the main determinant of permanent clinical disability. However, the role of axonal loss early in disease or during relapsing-remitting disease is still under investigation, as are the interactions and interdependency between inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of MS. (c) 2006 Elsevier B.V. All rights reserved.
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