Journal
PEPTIDES
Volume 28, Issue 1, Pages 169-173Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2006.06.013
Keywords
Cry toxins; Cyt toxins; Bacillus thuringiensis; receptor; binding epitopes; mode of action
Funding
- NIAID NIH HHS [1R01 AI066014-01] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI066014] Funding Source: NIH RePORTER
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Cry toxins from Bacillus thuringiensis are used for insect control. Their primary action is to lyse midgut epithelial cells. In this review we will summarize recent findings on the Cry toxin-receptor interaction and the role of receptor recognition in their mode of action. Cry toxins interact sequentially with multiple receptors. In lepidopteran insects, Cry1A monomeric toxins interact with the first receptor and this interaction triggers oligomerization of the toxins. The oligomer then interacts with second receptor inducing insertion into membrane microdomains and larval death. in the case of mosquitocidal toxins, Cry and Cyt toxins play a part. These toxins have a synergistic effect and Cyt1Aa overcomes Cry toxin resistance. Recently, it was proposed that Cyt1Aa synergizes or suppresses resistance to Cry toxins by functioning as a membrane-bound receptor for Cry toxin. (c) 2006 Elsevier Inc. All rights reserved.
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