Gastric emptying: a comparison of three methods

Objective. A better understanding of the clinical relevance of delayed gastric emptying ( e. g. in diabetes) requires a simple, easily accessible and inexpensive method for measuring it. Two new'' methods for measuring gastric emptying of liquids ( the paracetamol absorption test and the C-13-acetate breath test) are compared with the gold standard ( gastric emptying scintigraphy ( GES)). Material and methods. The three techniques were used simultaneously in 10 healthy subjects. A gastric emptying time-retention curve was drawn for each technique and the results were compared at the 75%, 50% and 25% retention quartiles. Results. Agreement was found between the paracetamol absorption test and GES ( p = 0.95; Hotelling's T-2 test). Using the Wagner-Nelson one compartment correction produced a retention curve for the C-13-acetate breath test statistically significantly below GES ( p <0.01). Conclusion. In healthy subjects, the paracetamol absorption test produced results comparable to those of liquid GES, but not to the results of the C-13-acetate breath test.