Journal
PEPTIDES
Volume 28, Issue 1, Pages 153-162Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2006.08.029
Keywords
insect control; angiotensin-converting enzyme; reproduction; peptidase; ANCE; ACE inhibitors
Funding
- Biotechnology and Biological Sciences Research Council [S19378] Funding Source: Medline
- Wellcome Trust [GR071921] Funding Source: Medline
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Insect angiotensin converting enzyme (ACE) is a zinc metallopeptidase capable of inactivating a variety of small to medium size peptide hormones by cleavage of C-terminal dipeptides and dipeptideamides. High levels of ACE activity are found in the hemolymph and in reproductive tissues of insects, where the enzyme is considered to have an important role in the metabolism of bioactive peptides. Therefore, inhibiting ACE activity is expected to interfere with the peptidergic endocrine system and to have detrimental effects on growth, development and reproduction. We will review the studies showing that ACE inhibitors do indeed disrupt growth and reproduction in various insect species. We will also present some new genetic and pharmacological data that strengthens our conclusion that ACE should be considered as a potential target for the development of new insect growth regulators. (c) 2006 Elsevier Inc. All rights reserved.
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