Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 57, Issue 1, Pages 172-180Publisher
WILEY
DOI: 10.1002/mrm.21118
Keywords
Alzheimer's disease; brain iron; MRI; R-2; relaxometry
Funding
- NIA NIH HHS [P50AG05136] Funding Source: Medline
- NIDDK NIH HHS [K24DK02957] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [K24DK002957] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P50AG005136] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Iron accumulates in the Alzheimer's disease (AD) brain and is directly associated with P-amyloid pathology. The proton transverse relaxation rate (R-2) has a strong linear relationship with iron concentrations in healthy brain tissue; however, an independent test of this relationship has not been extended to AD brain tissue. In this study in vitro single spin-echo (SE) measurements were made on tissue samples from four human AD brains using a 4.7T MRI research scanner. R-2 values were calculated for 14 cortical and subcortical gray matter (GM) and white matter (WM) regions. Atomic absorption spectroscopy was used to measure iron concentrations in the corresponding excised brain regions. Significant positive linear correlations were observed between R-2 values and iron concentrations in GM regions assessed across individual tissue samples and data averaged by brain region. With the use of a predictive model for R-2, a threshold iron concentration of 55 mu g Fe/g wet tissue was determined above which R-2 appears to be dominated by the affects of iron in AD brain tissue. High-field MRI may therefore be a useful research tool for assessing brain iron changes associated with AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available