Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 12, Issue -, Pages 2029-2037Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2208
Keywords
heart; myocardium; treatment; antioxidant; vitamins; injury; perfusion; infarction; reperfusion; arrhythmias; antioxidants; malondialdehyde; paraoxonase
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In myocardial infarctions with ST-segment elevation, ischemia followed by reperfusion ( IR) leads to arrhythmia, myocardial stunning and endothelial dysfunction injury by reactive oxygen species ( ROS). To determine the impact of ROS, we examined the effect of antioxidant vitamins on biochemical changes and arrhythmias induced by reperfusion before and after therapeutic thrombolysis ( Actilyse ((R))). As compared with those receiving placebo, in individuals who received antioxidants, there was a significant decrease in premature ventricular beats ( 100% vs 38%), atrial fibrillation ( 44% vs 6%), ventricular tachycardia ( 31% vs 0%), first- degree atrial- ventricular block ( 44% vs 6%), plasma malondialdehyde at the first hour after initiation of thrombolysis ( 1.07 +/- 0.10 vs 0.53 +/- 0.10 nmols plasma malondialdehyde/mg protein) and circulating neutrophils after 24 hr after reperfusion. The antioxidant capacity of plasma was increased from 1.89 +/- 0.15 to 3.00 +/- 0.31 units/ mg protein and paraoxonase-1 rose from 0.77 +/- 0.08 to 1.27 +/- 0.11 nmol/ min/ mg protein. These findings suggest that antioxidants might be useful as adjuvants in controlling reperfusion induced arrhythmias following therapeutic alteplase thrombolysis.
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