Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 182, Issue 1-2, Pages 212-218Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2006.09.013
Keywords
Guillain-Barre syndrome; ganglioside complex; antibody; disability
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Ganglioside complexes (GSCs) are known as target antigens in Guillain-Barre syndrome (GBS). To elucidate the clinical importance of the anti-GSC antibodies in GBS, We investigated serum antibodies to GSCs containing two of the gangliosides, GM1, GD1a, GD1b and GT1b, and analyzed clinical features of anti-GSC-positive GBS patients. Thirty-nine (17%) of 234 GBS patients had IgG anti-GSC antibodies. Anti-GSC-positive GBS had antecedent gastrointestinal infection and lower cranial nerve deficits more frequently than control GBS. The presence of antibody specificity to GD1a/GD1b and/or GD1b/GT1b was significantly associated with severe disability and a requirement for mechanical ventilation. (c) 2006 Elsevier B.V. All rights reserved.
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