Experience with the levonorgestrel-releasing intrauterine system among HIV-infected women

Background: Safe and effective contraception is needed for women infected with human immunodeficiency virus (HIV). The levonorgestrel-releasing intrauterine system (LNG-IUS) is an effective long-term contraceptive that reduces menstrual bleeding and may reduce the risk of pelvic inflammatory disease. Yet, little is known about LNG-IUS use in HIV-infected women. Subjects and Methods: Six HIV-infected women had the LNG-IUS inserted between March 1998 and October 2002, and were systemically followed for a mean of 45 months. Indications for LNG-IUS use were contraception in four women and menorrhagia in two women. Results: The LNG-IUS was well tolerated, and menstrual bleeding was reduced in all women. Blood hemoglobin levels increased in each subject, with mean levels being 123 g/L (SD= 11.7) before LNG-IUS insertion and 135 g/L (SD=8.7) at I year (p=.01). Levels of circulating CD4 lymphocytes and Pap smear findings remained unchanged. Conclusions: Our limited experience with LNG-IUS use in HIV-infected women is encouraging. The LNG-IUS may be used as an alternative to uterine surgery in HIV-infected women with menorrhagia. (c) 2007 Elsevier Inc. All rights reserved.