Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 26, Issue 6-7, Pages 589-595Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770701490282
Keywords
DNA G-quadruplex; molecular crowding; hydration; thermodynaimics
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Although water is an integral Part of DNA structures, the effects of water molecules on various DNA structures which are formed by not only Watson-Crick but also Hoogsteen base pairs are still unclear. Here, we studied quantitatively the effects of molecular crowding on the thermodynamics of a parallel G-quadruplex formation of [d(TG (4)) (2)](4) with Hoogsteen base pairs. It was demonstrated that molecular crowding conditions stabilized the parallel G-quadruplex. Moreover the plot of stability of the parallel C-quadruplex structure versus water activity suggested that water molecules were released through the G-quadruplex formation. The stabilization of the DNA structures consisting of Hoogsteen base pairs under cell-like conditions may lead to a structural polymorphism of various DNA sequences regulated by water molecules.
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