Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 26, Issue 10-12, Pages 1611-1613Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770701548733
Keywords
carborane; nucleoside; pharmacophor; click chemistry
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Modification of 2'-deoxyadenosine at position 8 with para-carborane boron cluster is described. Incorporation of boron cluster into nucleic base has been accomplished using Sonogashira palladium-catalyzed cross-coupling reaction or alternatively, Huisgen click type reaction. These are the first examples of adenosine derivatives with hydrophobic carborane pharmacophore attached to purine base.
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