Journal
NATURE METHODS
Volume 4, Issue 1, Pages 39-42Publisher
NATURE RESEARCH
DOI: 10.1038/NMETH975
Keywords
-
Categories
Ask authors/readers for more resources
The flagellate Euglena gracilis contains a photoactivated adenylyl cyclase (PAC), consisting of the flavoproteins PACa and PACb. Here we report functional expression of PACs in Xenopus laevis oocytes, HEK293 cells and in Drosophila melanogaster, where neuronal expression yields light-induced changes in behavior. The activity of PACs is strongly and reversibly enhanced by blue light, providing a powerful tool for light-induced manipulation of cAMP in animal cells. (c) 2007 Nature Publishing Group.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available