Journal
GENOME BIOLOGY
Volume 8, Issue 8, Pages -Publisher
BMC
DOI: 10.1186/gb-2007-8-8-r178
Keywords
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Funding
- NHGRI NIH HHS [1U01 HG004270-01, R01 HG004069-02, 1R01 HG004069-01, R01 HG004069, U01 HG004270] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [T32CA009337] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U01HG004270, R01HG004069] Funding Source: NIH RePORTER
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A novel normalization method based on the GC content of probes is developed for two-color tiling arrays. The proposed method, together with robust estimates of the model parameters, is shown to perform superbly on published data sets. A robust algorithm for detecting peak regions is also formulated and shown to perform well compared to other approaches. The tools have been implemented as a stand-alone Java program called MA2C, which can display various plots of statistical analysis for quality control.
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