Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 12, Issue -, Pages 214-221Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2059
Keywords
osteopontin; vascular inflammation; myocardial infarction; left ventricular hypertrophy; myocardial remodeling; coronary artery disease; valvular calcification
Categories
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL057947, R01HL071519, R01HL063070] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R15AI043310] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL-63070, HL-057947, R01 HL071519, HL-071519] Funding Source: Medline
- NIAID NIH HHS [AI-43310] Funding Source: Medline
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Osteopontin, also called cytokine Eta- 1, is a multifunctional protein containing Arg- Gly- Asp- Ser ( RGDS) cell- binding sequence. It interacts with alpha v beta 1, alpha v beta 3 and alpha v beta 5 integrins and CD44 receptors. OPN is suggested to play a role during inflammation via the recruitment and retention of macrophages and T-cells to inflamed sites. OPN regulates the production of inflammatory cytokines and nitric oxide in macrophages. In this review, we will discuss diverse roles of OPN related to cardiovascular diseases, including atherosclerosis, valvular stenosis, hypertrophy, myocardial infarction and heart failure.
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