Journal
MOLECULAR & CELLULAR PROTEOMICS
Volume 6, Issue 1, Pages 64-71Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/mcp.M600160-MCP200
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Funding
- DIVISION OF HEART AND VASCULAR DISEASES [N01HV028179] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [U01CA111244, R21CA114852] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI041109] Funding Source: NIH RePORTER
- NCI NIH HHS [U01-CA-111244, N01-CO-12400, R21-CA-114852] Funding Source: Medline
- NHLBI NIH HHS [N01-HV-28179] Funding Source: Medline
- NIAID NIH HHS [R01-AI-41109-01] Funding Source: Medline
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It has long been thought that blood plasma could serve as a window into the state of one's organs in health and disease because tissue-derived proteins represent a significant fraction of the plasma proteome. Although substantial technical progress has been made toward the goal of comprehensively analyzing the blood plasma proteome, the basic assumption that proteins derived from a variety of tissues could indeed be detectable in plasma using current proteomics technologies has not been rigorously tested. Here we provide evidence that such tissue-derived proteins are both present and detectable in plasma via direct mass spectrometric analysis of captured glycopeptides and thus provide a conceptual basis for plasma protein biomarker discovery and analysis.
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