Journal
LAB ON A CHIP
Volume 7, Issue 7, Pages 920-922Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b617939h
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Funding
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [K01EB003465] Funding Source: NIH RePORTER
- NIBIB NIH HHS [EB 003465] Funding Source: Medline
- NICHD NIH HHS [1R01 HD 051704-01A2] Funding Source: Medline
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We have developed a biological micro-electromechanical system (Bio-MEMS) device consisting of surface-modified microfabricated silicon cantilevers and an AFM detection apparatus for the study of cultured myotubes. With this system we are able to selectively stimulate the myotubes as well as report on a variety of physiological properties of the myotubes in real time and in a high-throughput manner. This system will serve as the foundation for future work integrating multiple tissue types for the creation of Bio-MEMS analogues of complex tissues and biological circuits.
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