Journal
NATURE METHODS
Volume 5, Issue 1, Pages 57-59Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH1147
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Funding
- NATIONAL CANCER INSTITUTE [U24CA126588, U54CA126505, P30CA068485, T32CA009582] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [T32EB001628, R01EB000214] Funding Source: NIH RePORTER
- NCI NIH HHS [P30 CA068485-139010, T32 CA009582, U24 CA126588-02, U54 CA126505-039002, U24 CA126588, U54 CA126505, P30 CA068485] Funding Source: Medline
- NIBIB NIH HHS [T32 EB001628, R01 EB000214, R01 EB000214-18, R01 EB000214-17] Funding Source: Medline
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We have developed a method for integrating three dimensional volume reconstructions of spatially resolved matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) ion images of whole mouse heads with high-resolution images from other modalities in an animal-specific manner. This approach enabled us to analyze proteomic profiles from MALDI IMS data with corresponding in vivo data provided by magnetic resonance imaging.
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