Journal
NATURE REVIEWS IMMUNOLOGY
Volume 8, Issue 10, Pages 802-815Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2415
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Funding
- Deutsche Forschungsgemeinschaft [DFC-FOR809]
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Chronic inflammation drives the development of atherosclerosis, and details regarding the involvement of different leukocyte subpopulations in the pathology of this disease have recently emerged. This Review highlights the surprising contribution of granulocyte subsets and mast cells to early atherogenesis and subsequent plaque instability, and describes the complex, double-edged role of monocyte, macrophage and dendritic-cell subsets through crosstalk with T cells and vascular progenitor cells. Improved understanding of the selective contributions of specific cell types to atherogenesis will pave the way for new targeted approaches to therapy.
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