Journal
NATURE REVIEWS CANCER
Volume 8, Issue 10, Pages 755-768Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2499
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Funding
- Victorian Breast Cancer Research Consortium
- National Health and Medical Research Council (Australia)
- National Breast Cancer Foundation (Australia)
- Susan G. Komen Breast Cancer Foundation
- US Department of Defense
- Australian Stem Cell Centre
- Australian Cancer Research Foundation
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Solid tumours are an enormous cancer burden and a major therapeutic challenge. The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours. There is increasing evidence that diverse solid tumours are hierarchically organized and sustained by a distinct subpopulation of CSCs. Direct evidence for the CSC hypothesis has recently emerged from mouse models of epithelial tumorigenesis, although alternative models of heterogeneity also seem to apply. The clinical relevance of CSCs remains a fundamental issue but preliminary findings indicate that specific targeting may be possible.
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