Journal
NATURE REVIEWS IMMUNOLOGY
Volume 8, Issue 4, Pages 259-268Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2276
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Funding
- NCI NIH HHS [R01 CA095137-05, R01 CA095137] Funding Source: Medline
- NIAID NIH HHS [P01 AI064520-040002, R01 AI068129-08, R37 AI066897-08, R01 AI068129, P01 AI064520, R37 AI066897] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA095137] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI064520, R37AI066897, R01AI068129] Funding Source: NIH RePORTER
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Natural killer (NK) cells are well recognized for their ability to provide a first line of defence against viral pathogens and they are increasingly being implicated in immune responses against certain bacterial and parasitic infections. Reciprocally, viruses have devised numerous strategies to evade the activation of NK cells and have influenced the evolution of NK-cell receptors and their ligands. NK cells contribute to host defence by their ability to rapidly secrete cytokines and chemokines, as well as to directly kill infected host cells. In addition to their participation in the immediate innate immune response against infection, interactions between NK cells and dendritic cells shape the nature of the subsequent adaptive immune response to pathogens.
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