Journal
NATURE REVIEWS IMMUNOLOGY
Volume 8, Issue 4, Pages 247-258Publisher
NATURE RESEARCH
DOI: 10.1038/nri2274
Keywords
-
Categories
Funding
- Intramural NIH HHS Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI005017, Z01AI005021, Z01AI005017, ZIAAI005016, Z01AI005018, ZIAAI005018, Z01AI005016, ZIAAI005021] Funding Source: NIH RePORTER
Ask authors/readers for more resources
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter flow cytometry has allowed a simultaneous assessment of the phenotype and multiple effector functions of single T cells; the delineation of T cells into distinct functional populations defines the quality of the response. New evidence suggests that the quality of T-cell responses is crucial for determining the disease outcome to various infections. This Review highlights the importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available