Journal
NATURE REVIEWS CANCER
Volume 8, Issue 3, Pages 193-204Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2342
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Funding
- MRC [G0700730] Funding Source: UKRI
- Cancer Research UK [8971] Funding Source: Medline
- Medical Research Council [G0700730] Funding Source: Medline
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DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects.
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