Journal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Volume 90, Issue 6, Pages 697-703Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/Y2012-049
Keywords
plastic consumables; bioactive leachates; polypropylene; pipette tips; microfuge tubes; bisphenol A; plasticizers; surfactants; stabilisers; antibacterials
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Funding
- Canadian Institutes of Health Research [MOP77529]
- Canada Foundation for Innovation [CFILOFS123945Holt]
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Plastic consumables, used universally in bioscience laboratories, are presumed inert with respect to bioassay outcomes. However, it is clear that many pipette tips, microfuge tubes, and other plastic disposables leach bioactive compounds into assay solutions, profoundly affecting data and experimental interpretation. In this paper we discuss the nature and sources of leachates and review several examples of compromised bioassay data that speak to the probable widespread nature of this largely unrecognised source of error. Strategies for minimizing leachate interferences are discussed.
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