Journal
NATURE IMMUNOLOGY
Volume 9, Issue 1, Pages 54-62Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1542
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI040098, R01AI040098] Funding Source: NIH RePORTER
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R37 AI040098-10, R37 AI040098, R37 AI040098-08, R37 AI040098-11, R37 AI040098-12, N01AI40098, R37 AI040098-09] Funding Source: Medline
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The splenic marginal zone is a site of blood flow, and the specialized B cell population that inhabits this compartment has been linked to the capture and follicular delivery of blood-borne antigens. However, the mechanism of this antigen transport has remained unknown. Here we show that marginal zone B cells were not confined to the marginal zone but continuously shuttled between the marginal zone and follicular areas, such that many of the cells visited a follicle every few hours. Migration to the follicle required the chemokine receptor CXCR5, whereas return to the marginal zone was promoted by the sphingosine 1-phosphate receptors S1P(1) and S1P(3). Treatment with an SIP, antagonist caused displacement of marginal zone B cells from the marginal zone. Marginal zone-follicle shuttling of marginal zone B cells provides an efficient mechanism for systemic antigen capture and delivery to follicular dendritic cells.
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