Journal
CELL DEATH AND DIFFERENTIATION
Volume 15, Issue 1, Pages 39-50Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cdd.4402247
Keywords
dendritic cells; apoptosis; immunity; tolerance
Categories
Funding
- NATIONAL CANCER INSTITUTE [R01CA089440, R01CA106802, R01CA078846, R01CA109465] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE [P50AT002779] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K08AI054375] Funding Source: NIH RePORTER
- NCCIH NIH HHS [AT 02779] Funding Source: Medline
- NCI NIH HHS [CA 078846, R01 CA106802-04, P01 CA 084514, R01 CA078846, R01 CA089440, R01 CA109465, R01 CA106802, CA109465, R01 CA 089440, CA 106802] Funding Source: Medline
- NIAID NIH HHS [K08 AI054375, AI 054375] Funding Source: Medline
Ask authors/readers for more resources
Dendritic cells (DCs) are antigen-presenting cells specialized to initiate and maintain immunity and tolerance. DCs initiate immune responses in a manner that depends on signals they receive from pathogens, surrounding cells and their products. Most tumors are infiltrated by DCs. Thus, interactions between DCs and dying tumor cells may determine the balance between immunity and tolerance to tumor cells. In addition, DCs also display non-immunologic effects on tumors and the tumor microenvironment. Therefore, improved understanding of the cross talk between tumor cells and DCs may suggest new approaches to improve cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available