Journal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Volume 88, Issue 3, Pages 264-272Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/Y10-014
Keywords
stress response; iron starvation; oxidative stress; small RNA; iron-sulfur clusters; regulatory proteins; RyhB
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC) [326831-06]
- Le Fonds quebecois de la recherche sur la nature et les technologies (FQRNT)
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Iron starvation and oxidative stress are 2 hurdles that bacteria must overcome to establish an infection. Pathogenic bacteria have developed many strategies to efficiently infect a broad range of hosts, including humans. The best characterized systems make use of regulatory proteins to sense the environment and adapt accordingly. For example, iron-sulfur clusters are critical for sensing the level and redox state of intracellular iron. The regulatory small RNA (sRNA) RyhB has recently been shown to play a central role in adaptation to iron starvation, while the sRNA OxyS coordinates cellular response to oxidative stress. These regulatory sRNAs are well conserved in many bacteria and have been shown to be essential for establishing a successful infection. An overview of the different strategies used by bacteria to cope with iron starvation and oxidative stress is presented here.
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