Journal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Volume 88, Issue 4, Pages 399-413Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/Y10-009
Keywords
oogenesis; folliculogenesis; paracrine signalling; KITL; GDF9; BMP15; cumulus cell; granulosa cell; connexin; gap junction; CX37; CX43; intercellular communication
Categories
Funding
- Medical Research Council of Canada
- Canadian Institutes of Health Research (CIHR)
- Children's Health Research Institute, London, Ontario
- CIHR Institute of Human Development, Child and Youth Health under Strategic Initiative
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Female fertility is determined to a large extent by the quality (developmental competence) of the oocyte as reflected in its ability to undergo meiosis, be fertilized, and give rise to a healthy embryo. Growth of the mammalian oocyte is coordinated with that of the follicle that encloses it by the actions of signals that pass in both directions between the germline and somatic components. This review summarizes what is known about the roles played by 2 different modes of intrafollicular signalling in oogenesis: paracrine factors activating receptors on the opposite cell type, and direct sharing of small molecules throughout the follicle via gap junction channels. Recent evidence indicates that these 2 modes of signalling interact to regulate oocyte growth and granulosa cell proliferation and that defects in either can contribute to female infertility.
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