Journal
GENE THERAPY
Volume 15, Issue 2, Pages 100-108Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.gt.3303004
Keywords
antioxidants; stem cell; protection
Categories
Funding
- NATIONAL CANCER INSTITUTE [R01CA083876] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI068021] Funding Source: NIH RePORTER
- NCI NIH HHS [CA083876] Funding Source: Medline
- NIAID NIH HHS [U19-AI068021] Funding Source: Medline
Ask authors/readers for more resources
Cytotoxic exposure of bone marrow and other non-hematopoietic organs containing self-renewing stem cell populations is associated with damage to the supportive microenvironment. Recent evidence indicates that radical oxygen species resulting from the initial oxidative stress persist for months after ionizing irradiation exposure of tissues including oral cavity, esophagus, lung and bone marrow. Antioxidant gene therapy using manganese superoxide dismutase plasmid liposomes has provided organ-specific radiation protection associated with delay or prevention of acute and late toxicity. Recent evidence has suggested that manganese superoxide dismutase transgene expression in cells of the organ microenvironment contributes significantly to the mechanism of protection. Incorporating this knowledge into designs of novel approaches for stem cell protection is addressed in the present review.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available