Journal
NATURE NANOTECHNOLOGY
Volume 3, Issue 1, Pages 41-45Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nnano.2007.386
Keywords
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Funding
- NIAID NIH HHS [U01 AI056546] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI056546] Funding Source: NIH RePORTER
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Conjugating proteins onto carbon nanotubes has numerous applications in biosensing(1,2), imaging and cellular delivery(3-5). However, remotely controlling the activity of proteins in these conjugates has never been demonstrated. Here we show that upon near-infrared irradiation, carbon nanotubes mediate the selective deactivation of proteins in situ by photochemical effects. We designed nanotube-peptide conjugates to selectively destroy the anthrax toxin, and also optically transparent coatings that can self-clean following either visible or near-infrared irradiation. Nanotube-assisted protein deactivation may be broadly applicable to the selective destruction of pathogens and cells, and will have applications ranging from antifouling coatings to functional proteomics.
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