Journal
CELL DEATH AND DIFFERENTIATION
Volume 15, Issue 1, Pages 70-79Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cdd.4402274
Keywords
apoptosis; autophagy; immunosurveillance; T-cell
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Cancer patients mount adaptive immune responses against their tumors. However, tumor develops many mechanisms to evade effective immunosurveillance. T-cell death caused by tumor plays a critical role in establishing tumor immunotolerance. Chronic stimulation of T cells by tumors leads to activation-induced cell death. Abortive stimulation of T cells by tolerogenic antigenpresenting cells loaded with tumor antigens leads to autonomous death of tumor-specific T cells. Therapeutic approaches that prevent T-cell death in the tumor microenvironment and tumor draining lymph nodes, therefore, should boost adaptive immune responses against cancer.
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