Journal
CLINICAL GENETICS
Volume 73, Issue 3, Pages 197-211Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1399-0004.2007.00946.x
Keywords
breast cancer; colorectal cancer; lung cancer; matrix metalloproteinases; polymorphism; SNP; survival; susceptibility
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The matrix metalloproteinases (MMPs) can degrade various components of the extracellular matrix and are implicated in the development and progression of cancer. There is evidence suggesting an association of MMP gene polymorphisms with cancer susceptibility and/or metastasis. This paper reviews the findings on several single nucleotide polymorphisms in the collagenase, stromelysin and gelatinase genes in lung cancer, breast cancer and colorectal cancer.
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