Journal
EXPERIMENTAL GERONTOLOGY
Volume 43, Issue 1, Pages 1-4Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2007.09.008
Keywords
genetics of aging; aging models; inflammation; immune response; dietary restriction; protein synthesis; drugs; longevity mutants
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Funding
- NATIONAL INSTITUTE ON AGING [P01AG008761, R01AG016219] Funding Source: NIH RePORTER
- NIA NIH HHS [P01 AG 08761, P01 AG008761-180006, P01 AG008761, R01 AG 16219, R01 AG016219-08, R01 AG016219] Funding Source: Medline
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This is the 25th anniversary of the discovery of extended longevity mutants in Caenorhabditis elegans. About one hundred papers describing results from studies on C elegans in aging research appeared this year. Many themes were pursued including dietary restriction, daf-9 action, the role of proteolysis and autophagy, and the continued search for more Age mutants. I use the word modulate not regulate so as to be consistent with the evolutionary theory of aging, which is also consistent with the empirical findings of all extended longevity (Age) mutants. These Age mutants universally result from deficits in known physiologic systems, rather than in some process designed to kill the animal in old age. (C) 2007 Elsevier Inc. All rights reserved.
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