Journal
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
Volume 39, Issue 4, Pages 416-435Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0317167100013937
Keywords
-
Categories
Funding
- Canadian Institutes of Health Research
- Alberta Heritage Foundation for Medical Research (AHFMR) studentship
- AHFMR Dr. Lionel E. McLeod Health Research Scholarship
Ask authors/readers for more resources
Neuropathic pain often fails to respond to conventional pain management procedures. Here we review the aetiology of neuropathic pain as would result from peripheral neuropathy or injury. We show that inflammatory mediators released from damaged nerves and tissue are responsible for triggering ectopic activity in primary afferents and that this, in turn, provokes increased spinal cord activity and the development of 'central sensitization'. Although evidence is mounting to support the role of interleukin-1 beta, prostaglandins and other cytokines in the onset of neuropathic pain, the clinical efficacy of drugs which antagonize or prevent the actions of these mediators is yet to be determined. Basic science findings do, however, support the use of pre-emptive analgesia during procedures which involve nerve manipulation and the use of anti-inflammatory steroids as soon as possible following traumatic nerve injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available